Science

Terpenes are cannabinoids

This article will set out two types of secondary metabolites that are biosynthesised by the plant Cannabis sativa L. and probably produce synergy with the effects cannabinoids.

It is being observed that cannabinoids are not the only active substances in the Cannabis plant. Certain studies showed that there were differences between the effects produced by pure cannabinoids and the ones caused by the plant, although cannabinoids are administered in equal doses in both cases. These observations point to the existence of other active substances in the Cannabis plant, which have an intrinsic pharmacological action and/or can modify the pharmacological action of cannabinoids. Two groups of active substances have been identified presently; terpenes and flavonoids, both of which appear in sufficient concentrations to have pharmacological activity. From a scientific perspective, neither which kind of specific compounds are capable of producing synergy with cannabinoids, nor how they are formed, have been proven. Both terpenes and flavonoids are under the increasing attention of the scientific and medical community due to their proven pharmacological actions. In the following paragraphs, we will try to show the current state of the studies about the biological and synergistic activity between these active substances and the cannabinoids.

Terpenes

Terpenes are volatile organic compounds formed by the union of hydrocarbon of 5 carbon atoms, known as isoprene. The smallest and most volatile compounds are monoterpenes, which are biosynthesised by the union of two isoprene molecules. The biggest and least volatile are biosynthesised by the union of three or more isoprene molecules. The sesquiterpenes are next in the chain, which are formed by the union of three isoprene molecules. Terpenes are secondary metabolites, which provide the plant with its organoleptic characteristics (aroma and flavour) and that constitutes most of the essential oil produced by aromatic plants.

Terpenes and cannabinoids share their biosynthetic pathways and, in fact, cannabinoids are terpeno-fenolic compounds one of which is CBD. In the Cannabis plant, terpenes also share the biosynthesis and accumulation spaces. Thus, both types of compounds are biosynthesised in the glandular trichomes of leaves and flowers and are accumulated in large proportions in the exuded resin. In any case, it seems that certain non-capitular glandular trichomes, which are more abundant in leaves surface, are specialised in synthesizing terpenes. It has been shown that the ratio between monoterpenes and sesquiterpenes in leaves and flowers is rather different. This is due to the dominance of sessile trichomes in leaves, which are more specialised in synthesizing terpenes, while capitate trichomes are more abundant in flowers and are specialised in the synthesis of monoterpenes and cannabinoids. The proportion of terpenes in the plant is normally less than 1%, potentially achieving up to 10% of the resin composition.

Functions of the Endocannabinoid System

The endocannabinoid system is perhaps the most crucial biological system involved in creating and maintaining optimum homeostasis in your body. The terpenes in Agora CBD™ along with its cannabinoids are believed to relate to CB1 and CB2 receptor sites. These sites are found nearly everywhere in your body. They are in your brain, tissues, organs, glands, and cells. In each region, CBD with Terpenes perform countless functions with one sole purpose, homeostasis. By consuming Agora CBD™ with its respective terpenes, homeostasis is believed to begin. It has been our experience to view the reactions at an unprecedented speed on many levels. Fundamentally, Agora CBD™ provides what we call an internal balance for human anatomy despite wildly accelerating changes and stress in your external environment.

One example we have seen is relief from inflammation and pain from chronic or acute injury while incurring no tolerance or dependence. Agora CBD™ appears to minimize pain and damage caused by an injury. Agora CBD™ may prevent your body from doing too much of a good thing when injured by inhibiting your body’s immune reaction from growing out of control. We are confident this is done by inhibiting activators such as histamine and C-reactive protein (CRP), therefore limiting inflammation. At the same time, Terpenes have been shown to throttle your nerve cells from excessive synaptic firing, acting as a potent pain reliever.

Another example in our view is that the homeostasis caused by Agora CBD™ is what we have seen to have a powerful effect on cancer and tumors. Studies show that CBD with terpenes may optimize normal cells while hunting down and killing cancer and tumor cells. Malignant cells produce a high amount of a compound that cannabinoids appear to be attracted to. This looks to cause an unhealthy cell to die, leaving only healthy cells and enhancing your body’s homeostasis at a whole new level.

CBD with terpenes has been researched for its anti-convulsant, anti-inflammatory, antioxidant, anti-psychotic, and immune system properties. CBD users are sown to have lower levels of C-reactive protein which is directly connected to cardiovascular disease and stroke. CBD has been shown to help with Alzheimer’s, arteriosclerosis, bowel disorders, cirrhosis, depression, diabetes (type 1 and 2), hypertension, metabolic syndrome, nausea, neuropathic pain, osteoarthritis, rheumatoid arthritis, and much more, all without causing tolerance or dependence.

Those that use the Agora CBD™ system, may very well cross over to a new paradigm of healing, promoting health, and preventing disease. We encourage you to browse the Internet and read the thousands of reputable studies about the CBD with terpenes.

**These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent disease.

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Frequently Asked Questions

Have a question? Here are some of the most common questions we receive. Don’t see the answer you were looking for? Feel free to ask your own questions HERE.

WHY SHOULD I USE AGORA CBD™?

Unlike chemically derived Terpenes, we do not alter the plant’s integrity. Agora CBD™ is extracted by a chemical-free process that invokes all of the plant’s natural synergy. We extract the natural fatty acids, waxes, minerals, and vitamins to create a potent phyto-rich, broad-spectrum, “as found in nature” supplement for your body.

We call this the “entourage effect,” which provides you the potential of Active Terpenes in their natural state. We are convinced this form of Terpene is the most efficacious and takes advantage of the whole plant interacting with your endocannabinoid system, just as nature intended.

Is CBD LEGAL?

Agora CBD™ is 100% legal anywhere in the World. This is because Agora CBD™ is derived from a natural plant. The FDA acknowledges that CBD is legal in the USA, enacted under the 2018 US Farm Bill.

HOW LONG Does CBD TAKE TO WORK?

This certainly varies from person to person as do the dosages. Most people take 10mg. – 40mg. per dosage and this could be a 10mg. gel cap or a dropper full of oil which comes in a 1-ounce bottle labeled 250 which is also 10mg. or 60mg. We have seen and heard that most people experience growing relief within as little as 20 minutes.

Frequently Asked Questions

Have a question? Here are some of the most common questions we receive. Don’t see the answer you were looking for? Feel free to ask your own questions HERE.

WHY SHOULD I USE AGORA CBD™?

Unlike chemically derived Terpenes, we do not alter the plant’s integrity. Agora CBD™ is extracted by a chemical-free process that invokes all of the plant’s natural synergy. We extract the natural fatty acids, waxes, minerals, and vitamins to create a potent phyto-rich, broad-spectrum, “as found in nature” supplement for your body.

We call this the “entourage effect,” which provides you the potential of Active Terpenes in their natural state. We are convinced this form of Terpene is the most efficacious and takes advantage of the whole plant interacting with your endocannabinoid system, just as nature intended.

Is CBD LEGAL?

Agora CBD™ is 100% legal anywhere in the World. This is because Agora CBD™ is derived from a natural plant. The FDA acknowledges that CBD is legal in the USA, enacted under the 2018 US Farm Bill.

HOW LONG DO Active Driven Terpenes TAKE TO WORK?

This certainly varies from person to person as do the dosages. Most people take 10mg. – 40mg. per dosage and this could be a 10mg. gel cap or a dropper full of oil which comes in a 1-ounce bottle labeled 250 which is also 10mg. or 60mg. We have seen and heard that most people experience growing relief within as little as 20 minutes.

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